| 20351 | Sean Curran (Secret Service) | 32,794 | 6 | 187 |
| 20352 | Sean Hayes | 43,029 | 6 | 95 |
| 20353 | Sean Lennon | 32,215 | 6 | 218 |
| 20354 | Sean O'Brien (labor leader) | 72,394 | 6 | 45 |
| 20355 | Sebastian Coe | 67,542 | 6 | 84 |
| 20356 | Sebastian Croft | 15,748 | 6 | 485 |
| 20357 | Sebastian Fundora | 77,024 | 6 | 42 |
| 20358 | Second ladies and gentlemen of the United States | 17,268 | 6 | 584 |
| 20359 | Second Modi ministry | 44,863 | 6 | 100 |
| 20360 | Second presidential transition of Donald Trump | 18,080 | 6 | 363 |
| 20361 | Secret Invasion | 25,825 | 6 | 201 |
| 20362 | Sectoral representation in the House of Representatives of the Philippines | 210,281 | 6 | 5 |
| 20363 | Sembi | 23,848 | 6 | 253 |
| 20364 | Senegal national football team | 24,258 | 6 | 215 |
| 20365 | Serbia national football team | 65,355 | 6 | 52 |
| 20366 | Serendipity's Embrace | 17,554 | 6 | 332 |
| 20367 | Sergio Rico | 42,294 | 6 | 95 |
| 20368 | Seven Kings Must Die | 95,725 | 6 | 17 |
| 20369 | Shadow Generations | 15,369 | 6 | 352 |
| 20370 | Shane Van Dyke | 22,378 | 6 | 272 |
| 20371 | Sharmeen Obaid-Chinoy | 34,016 | 6 | 109 |
| 20372 | Sharon Rooney | 20,067 | 6 | 424 |
| 20373 | Shaun Ryder | 29,653 | 6 | 139 |
| 20374 | Shekhar Suman | 16,833 | 6 | 419 |
| 20375 | Shelby Oaks | 16,749 | 6 | 280 |
| 20376 | Shericka Jackson | 20,888 | 6 | 299 |
| 20377 | Shi Yuqi | 41,098 | 6 | 154 |
| 20378 | Shiva Rajkumar filmography | 16,464 | 6 | 403 |
| 20379 | Shoeless Joe Jackson | 116,293 | 6 | 20 |
| 20380 | Shooting at the Summer Olympics | 22,559 | 6 | 345 |
| 20381 | Shooting of Charlie Kirk | 2,062,330 | 6 | 3 |
| 20382 | Shot put | 50,773 | 6 | 113 |
| 20383 | Shrek | 22,166 | 6 | 208 |
| 20384 | Si Jiahui | 34,491 | 6 | 131 |
| 20385 | Si Robertson | 96,214 | 6 | 22 |
| 20386 | Si Spencer | 19,175 | 6 | 381 |
| 20387 | Siblings Day | 30,867 | 6 | 116 |
| 20388 | Sienna Shaw | 15,467 | 6 | 447 |
| 20389 | Signal (software) | 97,391 | 6 | 24 |
| 20390 | Sikandar Raza | 21,153 | 6 | 340 |
| 20391 | Sikorsky UH-60 Black Hawk | 194,480 | 6 | 15 |
| 20392 | Silence (2016 film) | 22,277 | 6 | 206 |
| 20393 | Silvia Pinal | 98,999 | 6 | 18 |
| 20394 | Simon Birch | 25,858 | 6 | 276 |
| 20395 | Simon Yates (cyclist) | 50,753 | 6 | 68 |
| 20396 | Single sign-on | 21,373 | 6 | 278 |
| 20397 | Sinqua Walls | 19,834 | 6 | 353 |
| 20398 | Sinéad Keenan | 22,810 | 6 | 267 |
| 20399 | Sister Death | 21,332 | 6 | 320 |
| 20400 | Skip Bayless | 44,753 | 6 | 90 |