| 16451 | Sixto Rodriguez | 90,897 | 8 | 22 |
| 16452 | Siya Kolisi | 49,448 | 8 | 82 |
| 16453 | Skylar Thompson | 196,511 | 8 | 17 |
| 16454 | Small Things like These | 37,310 | 8 | 95 |
| 16455 | Smallville | 11,165 | 8 | 686 |
| 16456 | Smash Mouth | 495,519 | 8 | 5 |
| 16457 | Snake Eyes | 129,389 | 8 | 11 |
| 16458 | Snooker | 44,803 | 8 | 80 |
| 16459 | Sofiya Qureshi | 39,456 | 8 | 73 |
| 16460 | Solar eclipse of October 2, 2024 | 100,403 | 8 | 27 |
| 16461 | Solstice | 20,822 | 8 | 276 |
| 16462 | Somaliland | 44,662 | 8 | 119 |
| 16463 | Sommarøy | 12,361 | 8 | 541 |
| 16464 | Song Jae-lim | 301,581 | 8 | 7 |
| 16465 | Song Yadong | 45,698 | 8 | 120 |
| 16466 | Sorana Cîrstea | 32,198 | 8 | 125 |
| 16467 | South Africa national soccer team | 64,570 | 8 | 36 |
| 16468 | Southeast Asian Games | 17,676 | 8 | 452 |
| 16469 | Southeastern Conference | 14,880 | 8 | 618 |
| 16470 | Southern Syria clashes (July 2025–present) | 33,978 | 8 | 94 |
| 16471 | Space Shuttle Columbia | 27,520 | 8 | 212 |
| 16472 | Spam (electronic) | 10,617 | 8 | 802 |
| 16473 | Sriimurali | 38,996 | 8 | 136 |
| 16474 | Stan Kroenke | 259,930 | 8 | 6 |
| 16475 | Star Wars Day | 96,332 | 8 | 22 |
| 16476 | Star Wars Jedi: Fallen Order | 24,610 | 8 | 234 |
| 16477 | Star Wars: Episode I – The Phantom Menace | 23,965 | 8 | 256 |
| 16478 | State Farm Stadium | 94,682 | 8 | 57 |
| 16479 | Steeplechase | 135,614 | 8 | 24 |
| 16480 | Stephen Harper | 35,893 | 8 | 128 |
| 16481 | Stephen Thompson (fighter) | 65,023 | 8 | 49 |
| 16482 | Steve Wright | 284,425 | 8 | 7 |
| 16483 | Sticky Vicky | 72,072 | 8 | 34 |
| 16484 | Street Fighter (2026 film) | 38,217 | 8 | 105 |
| 16485 | Street Fighter 6 | 21,205 | 8 | 245 |
| 16486 | Strictly Come Dancing series 23 | 46,562 | 8 | 72 |
| 16487 | Sublime (band) | 45,913 | 8 | 119 |
| 16488 | Succession to the British throne | 58,158 | 8 | 104 |
| 16489 | Suits: L.A. | 16,685 | 8 | 456 |
| 16490 | Sukhoi Su-35 | 22,443 | 8 | 201 |
| 16491 | SungWon Cho | 18,048 | 8 | 313 |
| 16492 | Super Bowl LXI | 63,854 | 8 | 92 |
| 16493 | Super Bowl XLII | 36,682 | 8 | 171 |
| 16494 | Super Bowl XXXIX | 41,048 | 8 | 160 |
| 16495 | Super Mario | 20,887 | 8 | 317 |
| 16496 | Super Mario RPG | 41,031 | 8 | 114 |
| 16497 | Superconductivity | 33,625 | 8 | 112 |
| 16498 | Supercoppa Italiana | 42,595 | 8 | 148 |
| 16499 | Surveen Chawla | 22,465 | 8 | 311 |
| 16500 | Susan Boyle | 39,128 | 8 | 116 |